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KMID : 1189420040170010045
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2004 Volume.17 No. 1 p.45 ~ p.54
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The Experimental Stydy on the Anti-Allergic Rhinitis Effects of the Gamigyeji-tang
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Sim Sung-Yong
Kim Kyung-Jun
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Abstract
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Major symptoms of allergic rhinitis are nasal obstructions, sneezing and watery rhinorrhea. Gamigyeji-tang has been used to treat for watery rhinorrhea, which is one of the symptoms of allergic rhinitis. This experimental study was done to rescarch effects of Gamigyeji-tang. We have studied effect of mice on OVA-induced Production of IL-4, IL-5, IFN-Υ by Murine Splenocytes, and effect of OVA-induced total IgE and OVA-Specific IgE. The results were as follows ; 1. In IL-4 study, Gamigyeji-tang treated group was proved significant inhibitory effect(p〈0.005) 2. In IL-5 study, Gamigyeji-tang treated group was proved significant inhibitory effect.(p〈0.05) 3. In IFN-Υ study, Gamigyeji-tang treated group was proved significant inhibitory effect(p〈0.000001) 4. In Total IgE, Gamigyeji-tang treated group didn't showed significant inhibitory effect. 5. In OVA-specific IgE, Gamigyeji-tang treated group didn't showed significant inhibitory effect. According to this result, Gamigyejj-tang was concluded to be effective on anti-allergic action. More studies are required to investigate the mechanism of inhibition by herbal medicine in allergic rhinitis model.
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KEYWORD
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Allergic Rhinitis , Gamigyejj-tang , IL-4 , IL-5 , IFN-v , IgE , ovalbumin
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